Limna - Lausanne Integrative Metabolism Nutrition Alliance

Johannes Gräff

Nestle Chair for Neuroscience - Brain Mind Institute - EPFL

Our lab is interested in three main questions. How and where are long-term memories stored in the brain? Why are memories lost during neurodegeneration such as in Alzheimer's Disease? How can traumatic memories from the past be overcome? 

To answer these questions, our lab focuses on the emerging field of neuroepigenetics. "Epi-genetic" mechanisms, i.e. modifications to the chromatin that regulate gene expression without changing the DNA sequence itself, have not only been shown to react to fluctuating environmental contingencies, but also to encode the cell fate of neurons and other cell types during development. With this Janus-faced property of being at once dynamic and stable, we believe that epigenetic mechanisms harbor the potential to better explain the molecular processes that govern learning, memory and memory loss. In extension, because epigenetic mechanisms are also amenable to pharmacological intervention, they might constitute a novel angle on how to counteract memory loss and resilient traumatic memories.


  • Epigenetics
  • Long-term memories
  • Traumatic memories
  • Memory loss
  • Neurodegeneration
  • Alzheimer's Disease


Prof. Johannes Gräff
Brain Mind Institute



Bâtiment AI 2137.1
Station 19
CH-1015 Lausanne

Tel +41 21 693 07 13
Fax +41 21 693 18 97
Lab website