Over the past years metabolism has emerged as major regulator of stem and immune cells function and activation. Indeed recent studies have shown that metabolic interventions both in animal model and in human can profoundly alter stem and immune cell function.

In this context, the primary research goal of my group is to understand the metabolic de-regulation occurring during aging in the hematopoietic and immune compartments. We are currently developing targeted metabolic/nutritional therapies that can prevent/revert the aging processes, improve stem and immune function and enhance tumor immunotherapy and immunosurveillance. 

Specific interests include metabolic treatment for immunotherapy non-responders, metabolic reprogramming of myeloid biased HSC in aged and chemotherapy-treated patients, development of novel methods to boost blood reconstitution in transplanted patients and understanding the metabolic features of T cell exhaustion. 

Keywords

• Hematopoietic stem cells
• T cells
• Metabolism
• Aging
• Chemotherapy
• T cell exhaustion