Autophagy and cancer – a story with a sweet ending
ISREC Special seminar
Prof. Kevin Ryan
Beatson Institute for Cancer Research, Glasgow
Host: Prof. Etienne Meylan
Recent papers:
- Loss of autophagy causes a synthetic lethal deficiency in DNA repair. Liu EY, Xu N, O'Prey J, Lao LY, Joshi S, Long JS, O'Prey M, Croft DR, Beaumatin F, Baudot AD, Mrschtik M, Rosenfeldt M, Zhang Y, Gillespie DA,Ryan KM. Proc Natl Acad Sci U S A. 2015 Jan 20;112(3):773-8.
- p53 status determines the role of autophagy in pancreatic tumour development. Rosenfeldt MT, O'Prey J, Morton JP, Nixon C, MacKay G, Mrowinska A, Au A, Rai TS, Zheng L, Ridgway R, Adams PD, Anderson KI, Gottlieb E, Sansom OJ, Ryan KM. Nature. 2013 Dec 12;504(7479):296-300.
- Extracellular adenosine sensing-a metabolic cell death priming mechanism downstream of p53. Long JS, Crighton D, O'Prey J, Mackay G, Zheng L, Palmer TM, Gottlieb E, Ryan KM. Mol Cell. 2013 May 9;50(3):394-406.