Limna - Lausanne Integrative Metabolism Nutrition Alliance


Friday 5th February 2016
9h00 - EPFL, Route cantonale, 1015 Lausanne, SV Building, Room SV1717.1.

Autophagy and cancer – a story with a sweet ending

ISREC Special seminar 

Prof. Kevin Ryan

Beatson Institute for Cancer Research, Glasgow

Host: Prof. Etienne Meylan

Recent papers:

  • Loss of autophagy causes a synthetic lethal deficiency in DNA repair. Liu EY, Xu N, O'Prey J, Lao LY, Joshi S, Long JS, O'Prey M, Croft DR, Beaumatin F, Baudot AD, Mrschtik M, Rosenfeldt M, Zhang Y, Gillespie DA,Ryan KM. Proc Natl Acad Sci U S A. 2015 Jan 20;112(3):773-8.
  • p53 status determines the role of autophagy in pancreatic tumour development. Rosenfeldt MT, O'Prey J, Morton JP, Nixon C, MacKay G, Mrowinska A, Au A, Rai TS, Zheng L, Ridgway R, Adams PD, Anderson KI, Gottlieb E, Sansom OJ, Ryan KM. Nature. 2013 Dec 12;504(7479):296-300.
  • Extracellular adenosine sensing-a metabolic cell death priming mechanism downstream of p53. Long JS, Crighton D, O'Prey J, Mackay G, Zheng L, Palmer TM, Gottlieb E, Ryan KM. Mol Cell. 2013 May 9;50(3):394-406.