Abnormalities in glucose metabolism, vascular function and hematopoietic cells in Shb knockout mice: a role for the SHB adapter protein in the regulation of homeostasis

SEMINAR

Prof. MICHAEL WELSH

Department of Medical Cell Biology, UPPSALA, Sweden

Research interest: The research is focused on the SHB gene and its importance for homeostasis. Pleiotropic effects as a consequence of Shb gene deletion on female reproduction, glucose homeostasis, angiogenesis, hematopoietic stem cell function and T cell responses have been observed. The relevance of SHB signaling in the context of human diabetes, ischemic disease, allergy and tumor biology is currently being explored.

Host: Prof. Christian Widmann

• _{Alenkvist, I., Dyachok, O., Tian, G., Li, J., Mehrabanfar, S., Jin, Y., Birnir, B., Tengholm, A., Welsh, M. Absence of Shb impairs insulin secretion by elevated FAK activity in pancreatic islets. J Endocrinol, 223, 267- 275, 2014.}
• _{Gustafsson, K., Willebrand, E., Welsh, M. Absence of the adapter protein Shb potentiates the T helper type 2 response in a mouse model of atopic dermatitis. Immunology, 143, 33-41, 2014.}
• _{Funa, N. S., Kriz, V., Zang, G., Calounova, G., Åkerblom, B., Mares, J., Larsson, E., Sun, Y., Betsholtz, Welsh, M. Dysfunctional microvasculature as a consequence of Shb gene inactivation causes impaired tumor growth. Cancer Res. 69, 2141-2148, 2009.}