University of Southern Denmark, Odense (DK)
Research in the Mandrup Group focuses on understanding transcriptional networks regulating metabolism and stem cell development of mammalian cells. We are specifically interested in the molecular cross-talk between transcriptional regulation and metabolism in fat cells and the insulinproduing beta-cells in the pancreas, and in the transcriptional network regulating fat cell development. Fat cells and beta-cells play a central role in the etiology of insulin resistance and type II diabetes, and maintenance of proper carbohydrate/lipid homeostasis in these cells are of outmost importance for whole body physiology. The mechanisms of action and the gene regulatory programs initiated by members of the peroxisome proliferator activated receptor (PPAR) family and their associated co-factors are of particular interest. In addition, the Mandrup laboratory has a longstanding interest in the acyl-CoA binding protein (ACBP).
Host: Prof. Bart Deplancke