Limna - Lausanne Integrative Metabolism Nutrition Alliance

MD
Mauro Oddo

Service of Medical-Surgical Critical Care Medicine - CHUV

Our group is conducting clinically oriented research focused on the exploration of the injured human brain using modern tools that combine cerebral metabolic monitoring (and particularly the intra-cerebral microdialysis technique) with neuroimaging. We are particularly interested in deciphering the regulation of cerebral energy metabolism after brain injury (neurotrauma and ischemic stroke) in humans and to test novel therapeutic interventions that modulate neuroenergetics during the acute phase and may potentially translate into improved patient outcomes.

We employ a translational approach, making use of interventional trials in brain-injured patients monitored with intra-cerebral microdialysis and observational studies in our cohort of brain monitored patients.

Our studies are currently focusing on:

  1. Interventional study to test the effect of hypertonic lactate infusion on cerebral energy metabolism after traumatic brain injury (TBI) and ischemic stroke following subarachnoid hemorrhage due to a ruptured cerebral aneurysm (SAH)
  2. Interventional study to compare the effect of hypertonic lactate vs. standard hypertonic saline to treat cerebral edema following TBI
  3. Pilot trial to assess the effect of ketogenic diet on cerebral energy metabolism
  4. Study of the modulation of brain metabolic response to traumatic and ischemic injury and the role of lactate as alternative substrate to glucose
  5. The study of metabolomics in patients with brain injury

Our translational research exploits a multidisciplinary platform, involving the collaboration between clinician and fundamental scientists at the CHUV (Department of Clinical Neurosciences and Medical Radiology), the UNIL (Department of Physiology and Center of Biomedical Imaging) and the EPFL (Brain Mind Institute, Laboratory of Neuroenergetics and Cellular Dynamics).

Our research is funded by the Swiss National Science Foundation and the Novartis Foundation for Biomedical Research.

Keywords

Metabolism, Neuroenergetics, Lactate, Cerebral microdialysis, Brain injury.

Contact

Professor Mauro Oddo

Head Physician, Department of Medical-Surgical Intensive Care

Director, Clinical Research Unit

Neuroscience Critical Care Research Group

Rue du Bugnon 46; BH 08.623

Centre Hospitalier Universitaire Vaudois (CHUV) - Lausanne University Hospital

CH-1011 Lausanne, Switzerland

 

Associate Editor, Annals of Intensive Care

 

E-mail: mauro.oddo@chuv.ch

http://www.chuv.ch/soinsintensifs/sia_home/sia-recherche/sia-recherche-axes-de-recherche/sia-neuroreanimation.htm