Brain Mind Institute – Neurodegenerative studies Laboratory – EPFL
The Laboratory for the Study of Neurodegenerative Diseases is involved in exploring the cause of neurodegeneration in CNS pathologies including Amyotrophic Lateral Sclerosis as well as Parkinson’s and Alzheimer’s diseases. Our group develops and uses rodent models of disease for the validation of therapeutic approaches. Notably, we design viral vectors to introduce genetic information in the adult CNS, and we use these vectors for both animal modeling and gene therapy. The underlying roles of metabolic perturbations related to mitochondrial dysfunction and alterations of proteostasis during the aging process has become a major focus in our lab. We address these questions in the context of Parkinson’s disease by exploring the functional interaction between genes related to aging/longevity, and genetic determinants of familial forms of the disease including alpha-synuclein, parkin and PINK1.
Neurodegeneration, mitochondria, aging, proteostasis, rodent animal models, viral vectors, gene therapy, Parkinson’s disease, Amyotrophic Lateral Sclerosis.