New insights in the role of E2F1 in liver pathology and CDK4 in insulin signaling pathways in white adipose tissue
Diabetes and cancer represent healtcare challenges in our industrialzed countries. Dysregulation of energy metabolism is a comon feature of these two diseases. Lluis Fajas and his team, try to understand the metabolic changes taking place during different physio-pathological conditions including these two diseases.
They have recently issued two publications in the "Journal of Clinical Investigation": E2F1 mediates sustained lipogenesis and contributes to hepatic steatosis and CDK4 is an essential insulin effector in adipocytes giving new insights in the role of these two factors in these diseases.