Limna - Lausanne Integrative Metabolism Nutrition Alliance

PAST EVENT: SEMINAR

Friday 27th January 2017
12h15 - Department of Physiology, Bugnon 7, Lausanne Seminar room, 6th floor

RETROGRADE SIGNALING IN RESPONSE TO THE INHIBITION OF MITOCHONDRIAL GENOME EXPRESSION.


SEMINAR

Dr. Sébastien Michel

Laboratory of Cellular Biochemistry and Biology, University of Namur, Belgium.

Mitochondria are multifunctional organelles and their maintenance is required for cell homeostasis and function. Upon organelle dysfunction, a mitochondrial-to-nucleus communication, known as retrograde signaling, triggers an orchestrated expression of nuclear genes to relieve the stress and/or compensate the defect. Among the transcription factors described to respond to mitochondrial stress, CHOP-10 is activated by respiratory chain inhibition, mitochondrial accumulation of unfolded proteins and mtDNA mutations. In this study, we show that altered/impaired expression of mtDNA induces CHOP-10 expression in a signaling pathway that depends on the eIF2α/ATF4 axis of the integrated stress response rather than on the mitochondrial unfolded protein response.

Host: Prof. Christian Widmann

References

Haynes, C.M., Fiorese, C.J., Lin, Y.F., 2013. Evaluating and responding to mitochondrial dysfunction: the mitochondrial unfolded-protein response and beyond. Trends in cell biology 23, 311-318.

Michel, S., Canonne, M., Arnould, T., Renard, P., 2015. Inhibition of mitochondrial genome expression triggers the activation of CHOP-10 by a cell signaling dependent on the integrated stress response but not the mitochondrial unfolded protein response. Mitochondrion 21C, 58-68.