Unraveling key mechanisms of metabolic homeostasis and tumorigenesis by nutritional overload
Dr. Giorgio Ramadori
Department of Cell Biology and Metabolism · University of Geneva
Despite intense research, the primary defects causing obesity and diabetes are still largely unknown. High-calorie feeding is a well-known cause of these pathologies. Our research aims at understanding events associated with diet-induced obesity and diabetes, with particular focus on brain-signaling networks.
Conditions caused by high-calorie feeding (i.e. obesity and diabetes) are associated with increased incidence of cancer. Thus, we want to exploit the effects of nutritional overload on tumor biology with the aim to get insights into the mechanisms of cancer pathogenesis, ultimately unraveling cancer requirements and vulnerabilities that could be targeted for therapy.
Host: Prof. Lluis Fajas
- Ramadori, G., Konstantinidou, G., Venkateswaran, N., Biscotti, T., Morlock, L., Galié, M., Williams, S.N., Luchetti, M., Santinelli, A., Scaglioni, P.P., and Coppari R. 2014. Diet-induced unresolved ER-stress hinders KRAS-driven lung tumorigenesis. Cell Metabolism (doi: 10.1016/j.cmet.2014.11.020.)
- Ramadori, G., Fujikawa, T., Anderson, J., Berglund, E.D., Frazao, R., Michan, S., Vianna, C.R., Sinclair, D.A., Elias, C.F., and Coppari, R. 2011. SIRT1 deacetylase in SF1 neurons protects against metabolic imbalance. Cell Metabolism 14:301-312.
- Ramadori, G., Fujikawa, T., Fukuda, M., Anderson, J., Morgan, D.A., Mostoslavsky, R., Stuart, R.C., Perello, M., Vianna, C.R., Nillni, E.A., Rahmouni K., and Coppari R. 2010. SIRT1 deacetylase in POMC neurons is required for homeostatic defenses against diet-induced obesity. Cell Metabolism 12:78-87.