Centro Nacional de Investigaciones Oncológicas · Cell Division and Cancer Group, Madrid
Deregulation of the cell cycle is a common feature in human cancer. Our group focuses in deciphering the mechanisms by which cell division and cell proliferation are regulated. During the last years we have used mouse models to understand the relevance of several cell cycle regulators, including cell cycle kinases and phosphatases, as well as regulatory complexes involved in ubiquitin-dependent degradation of proteins, in the control of cell division and normal physiology of different cell types or tissues. Our current interests are i) to understand the basic control mechanisms that regulate the various cell division cycles that are present in mammalian cells; ii) to characterize the physiological and therapeutic consequences of cell cycle deregulation in vivo; iii) characterizing the function of microRNAs in cell biology and tumor development as well as their potential use in anti-tumoral therapies; and iv), understanding how progenitor cells and cancer stem cells control their self-renewal and proliferative properties. As a final goal, we aim to generate information that may be useful to improve therapeutic strategies against cancer cell proliferation.
Host: Prof. LLuis Fajas