Cancer Research Institute, Molecular Basis of Carcinogenesis Lab, Montpellier, FR
Our team is interested in molecular circuitries implicated in cellular senescence and stem cell function, and how deregulation of these biological processes affects organismal aging and tumorigenesis. Our project aims at characterizing new regulatory mechanisms of the p53 pathway, including those implicating the multifunctional protein E4F1 and the Mdm2 oncoprotein. Both E4F1 and Mdm2 are E3 ligases that regulate p53 at the post-translational level. In the past years, we identified atypical functions of those important regulators of the p53 pathway and found that they regulate various aspects of energy metabolism. Using genetically engineered mouse models, we are characterizing the impact of those complex metabolic networks in stem cell maintenance, normal tissue homeostasis and cancer development.
Host: Prof. Lluis Fajas